Comparision between Dexamethasone and Clonidine as an Adjuvant to zero point 5 percent Ropivacaine in Ultrasound Guided Pericapsular Nerve Group Block on Peri-operative Analgesia Among Patients Undergoing Total Hip Replacement Surgery at a Tertiary Care Hospital
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- To compare the time required for first rescue analgesia between Dexamethasone and Clonidine as adjuvants to 0.5% Ropivacaine in ultrasound-guided Pericapsular Nerve Group (PENG) block among patients undergoing total hip replacement surgery.
研究概览
简要总结
This study is a prospective randomized controlled trial designed to compare the efficacy of dexamethasone versus clonidine as adjuvants to point five per cent ropivacaine in ultrasound guided Pericapsular Nerve Group block for perioperative analgesia in patients undergoing total hip replacement surgery.
A total of 52 patients belonging to ASA class 1 and 2 and aged between 18 and 70 years will be included. Participants will be randomly allocated into two groups using computer generated block randomisation.
Group A will receive ropivacaine with dexamethasone Group B will receive ropivacaine with clonidine
The primary outcome measure is the time to first rescue analgesia.
Secondary outcome measures include ease of spinal positioning postoperative pain scores using a numeric rating scale at rest and at 15 degree leg elevation at multiple time intervals up to 24 hours and total analgesic consumption in the first 24 hours.
All patients will receive standardized spinal anesthesia and postoperative analgesia with paracetamol and fentanyl as rescue analgesic when required.
The study will be conducted over a period of 18 months at AIIMS Jammu. Statistical analysis will be performed using appropriate tests as per objective
The aim of the study is to identify the better adjuvant that prolongs duration of analgesia reduces opioid requirement and improves perioperative pain management in patients undergoing hip surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects of any gender Subjects aged between 18 to 70 years Subjects with American Society of Anaesthesiologists status one and two who are planned for hip surgeries.
排除标准
- •patient refusal pregnant women and pediatric population use of chronic opioids a history of preexisting neuropathies, seizures, previous neurological deficits those with severe chronic obstructive pulmonary disease coagulopathy body mass index more than or equal to 35kg msquare history of allergy contradiction to any drugs involved in this study a history of other chronic pain diseases skin rupture and infection at the puncture site.
结局指标
主要结局
To compare the time required for first rescue analgesia between Dexamethasone and Clonidine as adjuvants to 0.5% Ropivacaine in ultrasound-guided Pericapsular Nerve Group (PENG) block among patients undergoing total hip replacement surgery.
时间窗: 4hours, 8hours, 12 hours, 18 hours, 24 hours
次要结局
- 1) To compare the Ease Of Spinal Positioning (EOSP) between both adjuvants after PENG block, for spinal anaesthesia.(2)To determine Numerical Rating Scale pain Scores at rest & at 15° leg elevation in both the groups undergoing the respective blocks at first 4,8,12,18,24 hours in the post operative period.)
研究者
PRATEEKSHA S
ALL INDIA INSTITUTE OF MEDICAL SCIENCES-VIJAYPUR,JAMMU