Inhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis

Completed

• Conditions: Respiratory - Other respiratory disorders / diseases; Preterm infant Mortality; Reproductive Health and Childbirth - Complications of newborn; Neurological - Other neurological disorders; Preterm infant morbidity e.g Chronic Lung Disease or severe adverse neurological events

• Registration Number: ACTRN12609000859280
• Lead Sponsor: ational Health and Medical Research Council, Clinical Trials Centre, University of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-10-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 3567

Inclusion Criteria

For the purposes of this meta-analysis it was decided to include any trials that were:

Studies will be included if they are randomised controlled trials
preterm infants (<37 weeks) receiving assisted ventilation

Exclusion Criteria

For the purposes of this meta-analysis it was decided to exclude any trials that were:

Non randomised controlled trials using term infants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
All cause of mortality or chronic lung disease (CLD) using best available definition e.g alive and Oxygen (O2) dependent at 36 weeks PMA ( Post Menstrual Age) if calculable, or trialist own definition. <br>Found in medical records[36 weeks PMA];Severe adverse neurological event after randomization (intraventricular hemorrhage (IVH) grade III or IV, or cystic periventricular leukomalacia (PVL) or other pathologies such as periventricular echodensity, periventricular cysts,ventriculomegaly or hydrocephalus) assessed using cranial ultrasound.[Assessed at 28 weeks and 36 weeks PMA]