Effects of tolerable high dose of Vitamin B12, B6 & Folate intake on Behavioral and psychological symptoms & Quality of life in patients with Alzheimer's disease

Mashhad University of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2022年1月11日

适应症

试验速览

暂无简介。

•Alzheimer’s type dementia (DSM-IV, mild and moderate MMSE score=12-24, Age =65)
•no mentioned past medical history of cardiovascular disease (heart attack, arrhythmia, any heart surgery, and PCI implantation), severe renal disease (Cl Cr. >30 ml/min), seizure, anemia or vitamin B deficiency, and diabetes mellitus ( FBS<126 mg/dl).
•the patient should not have any recorded family history of cardiovascular disease, Parkinson's disease, or any other psychological or neurological disorder.
•The patient recording must be free of alcohol or any substance abuse and vitamin B interactive drugs at least one month before starting the trial.
•each Patient should have a certain caregiver (a Nurse - a family member).

•Patients are excluded if they miss the interventions for more than 7 days.
•death by natural causes.
•voluntary exclusion.
•patients with reported severe side effects of vitamin B during the trial. ( vitamin B6 neurotoxicity, arrhythmia, ataxia, nausea, diarrhea, skin rash, abdominal discomfort, drowsiness seizure, and severe depression)

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