MR Elastography versus FibroScan for the non-invasive assessment of liver fibrosis in patients with chronic liver disease

• Conditions: liver fibrosis; scarring of liver parenchyma; 10019654

• Registration Number: NL-OMON33250
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 95

Inclusion Criteria

Patients over 18 years of age;
Patients suspected of chronic viral or chronic non-alcoholic liver disease with an indication for liver biopsy (ASAT elevated >60 mmol/l (n<=40 mmol/l));
Written informed consent

Exclusion Criteria

Patients under 18 years of age;
Alcohol consumption of >3 units/day for males and >2 units/day for females;
Patients who are pregnant;
Patients who are claustrophobic (MRI scanner);
Patients who have magnetic or radiofrequency sensitive implants (MRI scanner);
Patients with extreme obesity (MRI scanner)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessment of the diagnostic accuracy of MR Elastography in diagnosing liver<br /><br>fibrosis compared with FibroScan and histopathology in patients suspected of<br /><br>chronic viral liver disease and non-alcoholic fatty liver disease. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>*The feasibility of combining MR Elastography and proton MR Spectroscopy in<br /><br>non-alcoholic fatty liver disease to distinguish between simple steatosis and<br /><br>NASH.<br /><br>*The evaluation of antiviral treatment response with combined MR Elastography<br /><br>and MR Spectroscopy versus FibroScan in patients with chronic viral liver<br /><br>disease.<br /><br>*The influence of increased hepatic fat content and inflammatory activity on<br /><br>viscoelasticity measurements.<br /><br>*The burden of liver biopsy, MR Elastography and FibroScan.</p><br>