Renal MR Elastography: Normal Findings and Variability of Stiffness Measurements

Hospices Civils de Lyon1 site in 1 country10 target enrollmentMarch 2009

ConditionsHealthy

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Healthy
Sponsor: Hospices Civils de Lyon
Enrollment: 10
Locations: 1
Primary Endpoint: Variability of stiffness measurement (on repeat examination)
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

MR Elastography is a new technique aimed at non-invasively measuring the stiffness of tissues. It has recently given interesting results in the assessment of liver fibrosis.

The objectives of the current study are:

to develop an imaging protocol for MR Elastography of the kidneys;
To calculate the stiffness of normal kidneys;
To evaluate the variability of the measurements of kidney stiffness by repeating the procedure twice on the same volunteers.

Registry

clinicaltrials.gov

Start Date

March 2009

End Date

July 2009

Last Updated

6 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Hospices Civils de Lyon

Eligibility Criteria

Inclusion Criteria

•Age between 18 and 40
•Signed informed consent form
•Insured by the French Social Security

Exclusion Criteria

•Pregnancy
•Personal or familial history of kidney disease
•Hypertension
•Contraindication to MRI

Outcomes

Primary Outcomes

Variability of stiffness measurement (on repeat examination)

Time Frame: 2 months

Normal kidney stiffness (measured from MRE data)

Time Frame: 2 months

Secondary Outcomes

Percentage of partial and total technical failures(2 months)
Tolerance of the procedure(2 months)
Quality criteria of stiffness measurements (area of the ROIs used for measurement, mean induced displacement measured in the ROIs)(2 months)