Magnetic Resonance Elastography (MRE) of Uterine Fibroids
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Acquisition of MR elastography images for comparison.
研究概览
简要总结
The purpose of this study is to gain additional information regarding use of Magnetic Resonance Elastography (MRE) for uterine fibroid characterization. In this study, the investigators will use a new noninvasive technology, MRE, to further characterize the elastic properties of the uterine fibroids. To date, very little is known concerning how the tissue composition of the uterine fibroid may affect its treatment with Magnetic Resonance Guided Focused Ultrasound (MRgFUS).
In this study, the investigators will use a new noninvasive technology, magnetic resonance elastography (MRE), to further characterize the elastic properties of the uterine fibroids. This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids. It is known that some fibroids with increased T2-signal on Magnetic Resonance Imaging(MRI) can be more difficult to treat.
This information will be gathered during routine magnetic resonance imaging for symptomatic uterine fibroids.
详细描述
This is a single-site, non-randomized pilot study to determine whether Magnetic Resonance Elastography (MRE) can be optimized for clinical use as part of the patients routine clinical imaging and to correlate with MR signal characteristics of the uterine fibroid.
MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging protocol.
Aims:
Specific Aim 1: To acquire magnetic resonance elastography images on women who have a clinically ordered pelvic magnetic resonance imaging (MRI) for uterine fibroids.
Specific Aim 2: To examine the correlation between MRE stiffness values and MR T2 signal characteristics for uterine fibroids. For a subset of patients going on to surgery correlation with pathology can also be performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women able to give informed consent
- •Women having uterine imaging
排除标准
- •Women currently pregnant
- •Allergy to either gadolinium or iodinated contrast
- •Severe claustrophobia
- •Weight in excess of 250 pounds
结局指标
主要结局
Acquisition of MR elastography images for comparison.
时间窗: every six months
MRE is performed at the end of the examination after the standard Magnetic Resonance Imaging(MRI) protocol.
次要结局
- Examination of Magnetic Resonance Elastography stiffness values and MR T2.(every six months)
研究者
David A. Woodrum
David A. Woodrum, M.D., PhD.
Mayo Clinic