Optimum duration of antibiotics after surgery for bone infectio
- Conditions
- Health Condition 1: M864- Chronic osteomyelitis with draining sinus
- Registration Number
- CTRI/2021/02/031537
- Lead Sponsor
- Sri Sathya Sai Institute of Higher Medical Sciences Prasanthigram
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients presenting with symptoms of osteomyelitis of duration more than six months
2. Intraoperative isolation of an organism from bone culture that is susceptible to antibiotics (intravenous and oral) along with any one of the following (Diagnostic criteria)
A. Evidence of local inflammatory response, manifested as local pain, edema, erythema, warmth, or drainage.
B. Evidence of systemic inflammatory response, manifested as fever, elevated C---reactive protein (CRP) level, or white blood cell count.
C. Osteomyelitis-compatible findings on plain radiograph, computed tomography or magnetic resonance imaging (if indicated for surgical planning)
1.Children and adolescents
2.Recurrent chronic osteomyelitis (history of previous treatment)
3.Not willing follow up as per study protocol
4.Pregnancy
5.History of intake of steriods or immunosuppressive medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of recurrence rate in either groupTimepoint: 6 weeks, 3 months, 6 months, 1 year
- Secondary Outcome Measures
Name Time Method 1.Comparison of antibiotic related adverse events <br/ ><br>2.Comparison of cost of treatment in either groups <br/ ><br>3.Risk factor analysis for recurrence in both groups <br/ ><br>4.Correlation of preoperative, intraoperative and recurrence isolates <br/ ><br>Timepoint: Any time within 1 year from surgical debridement