Comparative evaluation of Dexmedetomidine as an adjuvant to 2 percent plain lignocaine and 2 percent lignocaine with 1:200,000 adrenaline as local anesthetic agents for surgical removal of impacted mandibular third molars
试验速览
- 阶段
- Phase 3 4
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- onset and duration of LA, hemodynamic stability by recording pulse rate, blood pressure and spo2 at different intervals of time and anti-inflammatory action by measuring mouth opening and facial swelling at 24-48-hour, 48-72-hour, and 1-week follow-up period
研究概览
简要总结
There has always been a constant search for more potent, effective, and better-handling local anaesthetic drugs and adjuvants in the field of anaesthesia. The purpose of this study is to compare the two adjuvants to lignocaine based on their properties of improving the time of onset of anesthesia, the duration of anesthesia, reducing surgical blood field, their effects on basic vitals of the body and if they possess any significant anti-inflammatory actions. Dexmedetomidine (DEX), an extensively selective alpha-2 receptor agonist, is progressively utilized in the perioperative phase, eliciting sedation, analgesia, anxiolysis, and inhibition of sympathetic tone. Lignocaine with adrenaline prolongs the duration as well as the depth of anesthesia and prevent or minimize the blood loss during surgical procedures by vaso-constrictive properties. This study compares the effects of 2% lignocaine with 1:200000 adrenaline to the combination of dexmedetomidine and 2% plain lignocaine injected for the inferior alveolar nerve and long buccal nerve block in patients undergoing surgical removal of an impacted mandibular third molar.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 45.00 Year(s)（—）
- 性别
- All
入选标准
- •patients with ASA 1 status patients with presence of impacted lower 3rd molar indicated for extraction.
排除标准
- •Participants with a history of drug abuse and alcohol intoxication -Patients with Immunocompromised status.
- •Patients with comorbidities such as hypertension and diabetes -Presence of any local infection, -Women on oral contraceptives or pregnant and nursing mothers -Patients allergic to the LA used in the study.
结局指标
主要结局
onset and duration of LA, hemodynamic stability by recording pulse rate, blood pressure and spo2 at different intervals of time and anti-inflammatory action by measuring mouth opening and facial swelling at 24-48-hour, 48-72-hour, and 1-week follow-up period
时间窗: baseline- pre operative, | postoperative - 24hrs- 48 hrs | post operative -48hrs to 72 hrs | post operative- 1 week
次要结局
- mouth opening/ VAS score after 3 days post operative(3 days post operative)
研究者
Kanishka Tyagi
subharti dental college and hospital