Effects of Anesthesia Quality Improvement on Outcomes of Patients With Planned ICU Admission: a Prospective Pre-post Intervention Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Incidence of postoperative complication
研究概览
简要总结
Intensive care unit (ICU) is an important part of perioperative management for high-risk patients but is associated with higher medical costs. Improper ICU admission may produce overtreatment without beneficial effects. In clinical practice, delayed recovery after general anesthesia is a common indication for ICU admission after surgery. The concept of Enhanced Recovery After Surgery recommends early extubation. The investigators suppose that, for patients with planned ICU admission after elective surgery, implementing anesthesia quality improvement including extubation in the operating room will reduce the rate of ICU admission after surgery without increasing complications.
详细描述
Intensive care unit (ICU) is an important part of perioperative management for high-risk patients but is associated with higher medical costs. Improper ICU admission may produce overtreatment without beneficial effects. Studies found that immediate ICU admission after surgery did not reduce the perioperative mortality. Some authors suggested that the indication of ICU admission should be the occurrence of postoperative complications, which will reasonably reduce the use of medical resources.
In clinical practice, delayed recovery after general anesthesia is a common indication for ICU admission after surgery. Old age, high ASA grade, respiratory complications, long duration surgery, large-volume fluid infusion, and use of vasopressors were main factors associated with delayed recovery. The concept of Enhanced Recovery After Surgery recommends early extubation after surgery. Studies showed that, for patients after organ transplantation, immediate extubation in the operating room can shorten hospital stay and reduce medical costs, without increasing mortality.
The investigators suppose that, for patients with planned ICU admission after elective surgery, implementing anesthesia quality improvement including extubation in the operating room will reduce the rate of ICU admission after surgery without increasing postoperative complications.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •Scheduled to undergo elective surgery.
- •Planned ICU admission after surgery.
排除标准
- •Refused to participate in the study.
- •ICU admission before surgery.
- •Unexpected ICU admission.
- •Other conditions that are considered unsuitable for study participation.
研究组 & 干预措施
Routine anesthesia care
• Implementing anesthesia management according to current routine practice.
干预措施: Routine anesthesia care (Other)
Improved anesthesia care
- Encourage regional anesthesia or combined regional-general anesthesia.
- Encourage goal-directed fluid therapy, lung-protective ventilation, and active warming during surgery.
- Encourage extubation in the operating room at the end of surgery.
- Encourage multimodal analgesia after surgery.
- Encourage strict indication for ICU admission after surgery.
干预措施: Improved anesthesia care (Other)
结局指标
主要结局
Incidence of postoperative complication
时间窗: Up to 30 days after surgery
Postoperative complications are defined as newly occurred medical conditions that are considered harmful to patients' recovery and require therapeutic intervention, that is grade II or higher on Clavin-Dindo classification.
次要结局
- Rate of ICU admission(On the 1 day of surgery)
- Incidence of postoperative delirium(Up to 5 days after surgery)
- Rate of delayed neurocognitive recovery(up to 7 days after surgery)
- Length of stay in hospital after surgery(Up to 30 days after surgery)
- Medical costs during hospitalization(Up to 30 days after surgery)
研究者
Dong-Xin Wang
Professor and Chairman, Department of Anesthesiology and Critical Care Medicine
Peking University First Hospital
