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临床试验/NCT05626153
NCT05626153已完成不适用

Effects of Anesthesia Quality Improvement on Outcomes of Patients With Planned ICU Admission: a Prospective Pre-post Intervention Study

Peking University First Hospital1 个研究点 分布在 1 个国家目标入组 1,500 人开始时间: 2023年2月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
1,500
试验地点
1
主要终点
Incidence of postoperative complication

研究概览

简要总结

Intensive care unit (ICU) is an important part of perioperative management for high-risk patients but is associated with higher medical costs. Improper ICU admission may produce overtreatment without beneficial effects. In clinical practice, delayed recovery after general anesthesia is a common indication for ICU admission after surgery. The concept of Enhanced Recovery After Surgery recommends early extubation. The investigators suppose that, for patients with planned ICU admission after elective surgery, implementing anesthesia quality improvement including extubation in the operating room will reduce the rate of ICU admission after surgery without increasing complications.

详细描述

Intensive care unit (ICU) is an important part of perioperative management for high-risk patients but is associated with higher medical costs. Improper ICU admission may produce overtreatment without beneficial effects. Studies found that immediate ICU admission after surgery did not reduce the perioperative mortality. Some authors suggested that the indication of ICU admission should be the occurrence of postoperative complications, which will reasonably reduce the use of medical resources.

In clinical practice, delayed recovery after general anesthesia is a common indication for ICU admission after surgery. Old age, high ASA grade, respiratory complications, long duration surgery, large-volume fluid infusion, and use of vasopressors were main factors associated with delayed recovery. The concept of Enhanced Recovery After Surgery recommends early extubation after surgery. Studies showed that, for patients after organ transplantation, immediate extubation in the operating room can shorten hospital stay and reduce medical costs, without increasing mortality.

The investigators suppose that, for patients with planned ICU admission after elective surgery, implementing anesthesia quality improvement including extubation in the operating room will reduce the rate of ICU admission after surgery without increasing postoperative complications.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Sequential
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Age ≥18 years.
  • •Scheduled to undergo elective surgery.
  • •Planned ICU admission after surgery.

排除标准

  • •Refused to participate in the study.
  • •ICU admission before surgery.
  • •Unexpected ICU admission.
  • •Other conditions that are considered unsuitable for study participation.

研究组 & 干预措施

Routine anesthesia care

Active Comparator

• Implementing anesthesia management according to current routine practice.

干预措施: Routine anesthesia care (Other)

Improved anesthesia care

Experimental
  • Encourage regional anesthesia or combined regional-general anesthesia.
  • Encourage goal-directed fluid therapy, lung-protective ventilation, and active warming during surgery.
  • Encourage extubation in the operating room at the end of surgery.
  • Encourage multimodal analgesia after surgery.
  • Encourage strict indication for ICU admission after surgery.

干预措施: Improved anesthesia care (Other)

结局指标

主要结局

Incidence of postoperative complication

时间窗: Up to 30 days after surgery

Postoperative complications are defined as newly occurred medical conditions that are considered harmful to patients' recovery and require therapeutic intervention, that is grade II or higher on Clavin-Dindo classification.

次要结局

  • Rate of ICU admission(On the 1 day of surgery)
  • Incidence of postoperative delirium(Up to 5 days after surgery)
  • Rate of delayed neurocognitive recovery(up to 7 days after surgery)
  • Length of stay in hospital after surgery(Up to 30 days after surgery)
  • Medical costs during hospitalization(Up to 30 days after surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dong-Xin Wang

Professor and Chairman, Department of Anesthesiology and Critical Care Medicine

Peking University First Hospital

研究点 (1)

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