Aetiology of treatment failure in HIV positive children and adolescents on boosted protease inhibitor based regimens.

Not Applicable

Recruiting

• Conditions: HIV/AIDS

• Registration Number: PACTR201502001028169

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

1.Parents/guardian willing to consent
2.Child willing to provide assent
3.Documented HIV positive antibody or antigen test
4.Child knows their HIV status
5.Aged between 6 and 16 years (that is, from the day of their sixth birthday up to the eve of their seventeenth birthday)
6.Registered at Harare hospital paediatric opportunistic infections clinic
7.On second line treatment (ATV/r based)
8.Have taken the above named second line treatment for at least 6 complete, consecutive months
9.Has virological and immunological treatment failure as defined by WHO 2012 criteria

Exclusion Criteria

1.Patients registered at other health centres who have been referred for specialist care at Harare hospital paediatric opportunistic infections clinic
2.On ATV/r as first line treatment
3.Patients who do not want to be followed up at home.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Virological failure

Secondary Outcome Measures

Name	Time	Method
Atazanavir concentration in hair