Effect of Omega-3 Supplementation on Serum Level and Gene Expression of IGF-1and IGFBP-3 in Men With CVD.
Phase 4
Completed
- Conditions
- Cardiovascular Disease
- Registration Number
- NCT02092584
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
The aim of this study is the comparison between the effects of supplementation with omega 3 or placebo for 8 weeks in serum level of IGF-1 and IGFBP-3 and gene expression of IGF-1 in patients with cardiovascular disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 31
Inclusion Criteria
- CVD patients 45- 65 years old, patients with ≥ 50% stenosis in at least one coronary angiogram demonstrated, body mass index in the range 18.5- 35, avoidance of dietary supplements, vitamins and herbal products at least 3 months before and throughout the intervention, willingness to participation,
Exclusion Criteria
- people who have used omega 3 supplements in last 3 months, having chronic renal disease , GI disease, hepatobiliary diseases, hematological disorders, hypo- or hyperthyroidism, Smokers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Serum Total Cholesterol Change from baseline at 2 months Serum HDL-C Change frome baseline at 2 months Serum LDL-C Change frome baseline at 2 months Serum TG Change frome baseline at 2 months Serum Fasting Blood Sugar(FBS) Change frome baseline at 2 months Serum Insulin Change frome baseline at 2 months Serum hsCRP Change frome baseline at 2 months Serum Insulin Like Growth Factor-1(IGF-1) Change frome baseline at 2 months Serum IGF binding protein 3(IGFBP-3) Change frome baseline at 2 months
- Secondary Outcome Measures
Name Time Method Gene Expression of IGF-1 Change frome baseline at 2 months Gene expression of IGFBP3 change from baseline at 2 months
Trial Locations
- Locations (1)
Tehran University of Medical Sciences
🇮🇷Tehran, Iran, Islamic Republic of
Tehran University of Medical Sciences🇮🇷Tehran, Iran, Islamic Republic of