MESS-study MRSA Eradication Study Skåne

Not Applicable

Completed

• Conditions: Throatcarriers of MRSA
• Interventions: Drug: Mupirocin; Drug: Rifampin+Clindamycine or Trimehoprimsulfa

• Registration Number: NCT01269541
• Lead Sponsor: Region Skane

Brief Summary

The purpose of this study is to determine whether systemic antibiotic treatment with rifampicin and clindamycine or trimethoprim-sulfa in addition to topical treatment with mupirocin is more effective than only topical treatment to eradicate MRSA in throatcarriers

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-01-03
• Study First Submitted QC: 2011-01-03
• Study First Posted: 2011-01-04
• Study Start: 2011-03-01
• Status Verified: 2015-05
• Primary Completion: 2015-05-01
• Study Completion: 2015-05-01
• Last Update Submitted: 2017-08-21
• Last Update Posted: 2017-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

Colonized with MRSA in the throat Older than 5 years MRSA-bacteria sensitive for Rifampicin and Clindamycine or Trimethoprimsulfa -

Exclusion Criteria

Allergy to the studymedication Healthcareworkers Pregnancy Active infection with MRSA Immunosuppression Treatment with other antibiotic during the studyperiod

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mupirocin	Rifampin+Clindamycine or Trimehoprimsulfa	Topical treatment
Rifampicin+Clindamycine or Trimethoprimsulfa	Rifampin+Clindamycine or Trimehoprimsulfa	Rifampicin 10 mg/kgx1xVII Clindamycine 300 mgx3xVII Trimethoprimsulfa 400mg/80mg 2x2
Mupirocin	Mupirocin	Topical treatment

Primary Outcome Measures

Name	Time	Method
Culture for MRSA	after 6 months

Trial Locations

Locations (6)

Kristianstad hospital; 🇸🇪 Kristianstad, Skåne, Sweden

Örebro university hospital; 🇸🇪 Örebro, Sweden

SUS Malmö; 🇸🇪 Malmö, Skåne, Sweden

Helsingborg hospital; 🇸🇪 Helsingborg, Skåne, Sweden

Karolinska university hospital; 🇸🇪 Stockholm, Sweden

Infectious department SUS Lund; 🇸🇪 Lund, Skåne, Sweden