Ventriculo-lumbar perfusion chemotherapy for Leptomeningeal carcinomatosis
Not Applicable
Completed
- Conditions
- Neoplasms
- Registration Number
- KCT0000082
- Lead Sponsor
- ational Cancer Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 56
Inclusion Criteria
1) diagnosis of leptomeningeal carcinomatosis (LMC) by either CSF cytology or definite MR findings
2) at least one symptom of LMC; headache or increased intracranial pressure
(> 15cm H2o), hydrocephalus, cranial neuropathy or cauda equine symptoms
3) patient agree to the experimental protocol
Exclusion Criteria
1)CSF pathway block on wholspine MRI or RI cisternography,
2)Brain space occupying lesion, which could possibly cause herniation
3)Hemorrhagic brain metastasis
4)More than grade 3 leucopenia (ANC < 1,000) or thrombocytopenia (< 50K)
5)Altered mentality as severe as verbal communication is not possible
6)Active systemic cancer progression, at which expected survival is less than 2 months.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cauda Equina symptoms;intracranial pressure ;altered mentality;Cranial neuropathy
- Secondary Outcome Measures
Name Time Method CSF MTX level;serum MTX level;CSF cytology;Carcinoembryonic antige (CEA)