Risk factors for Stillbirth: A multi-centre case control study

Not Applicable

Completed

• Conditions: Assess the risk factors for mothers who experience a stillbirth compared to mothers representative of the general population who have a livebirth; Investigate the role of undiagnosed viral infections as a possible cause of stillbirth.The ultimate aim of this study is to focus on finding answers for true unexplained stillbirths to hopefully help prevent them occuring in the future.; Investigate the role of undiagnosed viral infections as a possible cause of stillbirth.; The ultimate aim of this study is to focus on finding answers for true unexplained stillbirths to hopefully help prevent them occuring in the future.; Reproductive Health and Childbirth - Fetal medicine and complications of pregnancy; Reproductive Health and Childbirth - Antenatal care; Reproductive Health and Childbirth - Complications of newborn

• Registration Number: ACTRN12609000990224
• Lead Sponsor: Royal Prince Alfred Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-11-17
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

cases:

stillbirth infants born >= 32 weeks gestational age
singleton pregnancy

controls:
matched to case by Estimated Date of Confinement (EDC) and hospital

Exclusion Criteria

cases and controls:

known congential or chromosomal abnormality

aboriginal or torres straight island mother

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Infection is measured by taking samples of maternal and cord blood, small sample of placenta and umblical cord. Multiplex Polymerase Chain Reaction (PCR) viral testing is conducted.<br><br>Placental macro and mirco pathological findings are also conducted.[Maternal blood is taking during/ around the time of birth.<br><br>Cord blood, piece of placenta and cord is sampled immediately after birth.<br><br>The placenta is sent to pathology after birth.];fetal movements meausred by a fetal movement questionaire. 8 qualitative questions asking a range of differenent questions relating to fetal movements[recorded during the semi- structed interview (antenatally for controls and ranging from 1-6 weeks after birth for cases)]

Secondary Outcome Measures

Name	Time	Method
Obstetric history and other lifestyle factors[Recorded during the semi- structed interview (antenatally for controls and ranging from 1-6 weeks after birth for cases)]