NCT01585545Enrolling By Invitation不适用
Radiomic Assessment in NSCLC: Correlation Between Multiparametric Imaging Biomarkers and Genetic Biomarkers
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Functional and genomic profiling of lung cancer
研究概览
简要总结
The purpose of this study is to evaluate relationships between multiparametric imaging biomarkers and genetic analysis in NSCLC patients.
详细描述
To evaluate relationships between multiparametric imaging biomarkers(CT, PET/CT, MRI) and genetic analysis in NSCLC patients
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suspected lung cancer on chest CT or histologically proven NSCLC
- •Participant is being considered for the conventional/neoadjuvant/targeted chemotherapy or surgery
- •At least one measurable primary or other intrathoracic lesion >= 2cm, according to RECIST
- •Performance status of 0 to 2 on the ECOG scale
- •Age 20 years or older
- •Able to tolerable PET/CT and CT imaging required by protocol
- •Able to undergo percutaneous needle biopsy before and after chemotherapy
- •Able to give study-specific informed consent
排除标准
- •Poorly controlled diabetes
- •Contraindication for CT contrast agent
结局指标
主要结局
Functional and genomic profiling of lung cancer
时间窗: five years
Prognostic stratification will be evaluated using following parameters: 1. Quantitative and qualitative parameters from CT, PET, MRI 2. Genomic data of lung cancer samples
次要结局
- Precise prediction of pulmonary function such as ventilation and perfusion after the lung resection.(five years)
- Relationship between genomic and multiparametric imaging profiling(five years)
研究者
Ho Yun Lee
Assistant Professor
Samsung Medical Center
研究点 (1)
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