Which role do genetic polymorphisms play in relation to respiratory tract infections in children with Down syndrome ?

Recruiting

• Conditions: Down Syndrome; innate immunity; 10083624; 10027665; 10019815

• Registration Number: NL-OMON33938
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 600

Inclusion Criteria

1.written informed consent from both parents or legal guardian(s)
2. age 0 until 18 years
3. sex: male and female
4. Down syndrome: trisomy 21

Exclusion Criteria

1. not meeting inclusion criteria
2. Down syndrome: translocation or mozaicism

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To investigate the genetic variation in TLRs and related genes in children with<br /><br>DS compared to a cohort of healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To investigate if a relationship exists between certain genetic polymorphisms<br /><br>in TLR genes and an increased susceptibility to respiratory tract infections<br /><br>within the group children with DS.</p><br>