Role of genetic variability and susceptibility in occupational exposure to anesthetics

Not Applicable

Recruiting

• Conditions: Occupational exposure to other air contaminants; adverse effects in the therapeutic use of inhaled anaesthetics; genotoxicity; epigenomics; SP4.102.072.092.778.554; H01.158.273.180.350.074; Z57.3; Y48.0

• Registration Number: RBR-864jjk
• Lead Sponsor: Departamento de Anestesiologia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-08-07
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Professionals working in the operating room; occupationally exposed to anesthetics; both genders and healthy individuals not exposed to inhaled anesthetics as participants in the control group

Exclusion Criteria

Malignant disease carriers; carriers of infectious or inflammatory diseases; those who regularly use alcohol; smokers; users of illicit drugs; those who use medication and / or vitamin supplementation; individuals exposed to radiation

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
We will test the hypothesis that occupational exposure to waste anesthetic gases (WAG) results in epigenetic modifications, specifically methylation, as well as genetic modifications due to changes in gene expression, and that polymorphisms influence the individual response to WAG toxicity.

Secondary Outcome Measures

Name	Time	Method
Are not expected.