Comparison of Central and Peripheral Venous Catheters

Not Applicable

Completed

• Conditions: Respiratory Insufficiency; Shock; Coma

• Registration Number: NCT00122707
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The purpose of this study is to compare the mechanical and infectious complications of peripheral versus central venous catheters in critically ill patients. Group allocation will be performed by randomization.

Detailed Description

Critically ill patients require intravenous administration of fluids and drugs. This can be achieved via peripheral or central catheters. Each device is associated with both mechanical and infectious complications. Complications associated with central lines are judged to be more severe. Some patients actually require the insertion of a central line due to the venous toxicity of the drugs or to the necessity of making sure that the infusion is regularly administered (example: high dose catecholamine infusion). Some physicians believe that most Intensive Care Unit (ICU) patients should have a central venous line inserted, whereas others feel that some patients may receive active drugs via a peripheral line in selected instances. No study prospectively compared the feasibility, merits and complications of the two possibilities (i.e., central or peripheral venous line). This study includes patients that can receive either a central or a peripheral line (see inclusion criteria): mainly patients receiving large amounts of fluid, moderate doses of catecholamines or of drugs that may cause venous injury. Patients are randomized to receive either a peripheral or a central venous catheter. Endpoints are the rate of mechanical complications (difficulty in inserting the line, need for repeat insertion attempts, occurrence of arterial puncture, occurrence of pneumothorax) and of infectious complications (local catheter infection or catheter-related bloodstream infection).

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2004-04
• Status Verified: 2005-06
• Study First Submitted: 2005-07-19
• Study First Submitted QC: 2005-07-19
• Study First Posted: 2005-07-22
• Study Completion: 2005-10
• Last Update Submitted: 2006-03-21
• Last Update Posted: 2006-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Patients requiring low to moderate doses of continuous catecholamine administration in the ICU
• Patients with 2 failed attempts at inserting a peripheral line
• Patients who require daily change of lines

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Exclusion Criteria

• Patients aged less than 18 years
• Pregnancy
• Absolute necessity of central venous access (refractory shock/high dose catecholamine infusion)

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
failure to insert line
mechanical complications of intravenous line insertion
infectious complications of intravenous lines

Secondary Outcome Measures

Name	Time	Method
number of cross-overs (due to impossibility of inserting/maintaining a peripheral line)

Trial Locations

Locations (1)

Service de Réanimation, Hopital Louis Mourier; 🇫🇷 Colombes, France