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临床试验/NCT05321095
NCT05321095已完成不适用

Screening for Albuminuria at the First Line for Early Identification of Chronic Kidney Disease: a Pilot Study

General Practitioners Research Institute1 个研究点 分布在 1 个国家目标入组 141 人开始时间: 2021年11月25日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
141
试验地点
1
主要终点
The prevalence of elevated albuminuria

研究概览

简要总结

Early detection of kidney disease

详细描述

Early detection and appropriate treatment of kidney disease is important as this may prevent future cardiovascular complications and end-organ damage more effectively than intervention in more advanced stages of disease. There is a well-established relationship between albuminuria and renal- and cardiovascular disease. Elevated albuminuria has a relatively high prevalence in the general population (5-9%). The prevalence of albuminuria is even higher in high-risk patients with diabetes Mellitus, hypertension, obesity, cardiovascular disease and lipid disorders. Adequate treatment of albuminuria, preferable at early stages can prevent both cardiovascular and renal disease progression. However, scarce epidemiological data show that albuminuria measurements are only conducted in a minority of individuals and disease recognition is suboptimal, even in high-risk groups. The current study aims to evaluate if and how early identification of chronic kidney disease by targeted screening of albuminuria levels is feasible in primary care (pharmacies and general practitioners) to optimally discover and treat patients with elevated albuminuria.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Diabetes Mellitus (diagnosis or prescription for the disease based on the NHG guidelines)
  • Adipositas (diagnosis)
  • Hypertension (diagnosis or prescription for the disease based on the NHG guidelines)
  • Cardiovascular disease (diagnosis, specified in protocol section 5.2.2)
  • Lipid disorder (diagnosis or prescription for the disease based on the NHG guidelines)

排除标准

  • Inability to understand and sign the informed consent form
  • Pregnancy

结局指标

主要结局

The prevalence of elevated albuminuria

时间窗: 1-2 weeks after invitation

defined as a confirmed urinary albumin creatinine ratio (UACR) ≥ 3.0 mg/mmol.

次要结局

  • Average costs per subject(through study completion, an average of 5 weeks)
  • The prevalence of unknown elevated albuminuria(through study completion, an average of 5 weeks)
  • the proportion of invited subjects that was identified as having hidden kidney disease(through study completion, an average of 5 weeks)

研究者

发起方
General Practitioners Research Institute
申办方类型
Network
责任方
Sponsor

研究点 (1)

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