Screening for Albuminuria at the First Line for Early Identification of Chronic Kidney Disease: a Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 141
- 试验地点
- 1
- 主要终点
- The prevalence of elevated albuminuria
研究概览
简要总结
Early detection of kidney disease
详细描述
Early detection and appropriate treatment of kidney disease is important as this may prevent future cardiovascular complications and end-organ damage more effectively than intervention in more advanced stages of disease. There is a well-established relationship between albuminuria and renal- and cardiovascular disease. Elevated albuminuria has a relatively high prevalence in the general population (5-9%). The prevalence of albuminuria is even higher in high-risk patients with diabetes Mellitus, hypertension, obesity, cardiovascular disease and lipid disorders. Adequate treatment of albuminuria, preferable at early stages can prevent both cardiovascular and renal disease progression. However, scarce epidemiological data show that albuminuria measurements are only conducted in a minority of individuals and disease recognition is suboptimal, even in high-risk groups. The current study aims to evaluate if and how early identification of chronic kidney disease by targeted screening of albuminuria levels is feasible in primary care (pharmacies and general practitioners) to optimally discover and treat patients with elevated albuminuria.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diabetes Mellitus (diagnosis or prescription for the disease based on the NHG guidelines)
- •Adipositas (diagnosis)
- •Hypertension (diagnosis or prescription for the disease based on the NHG guidelines)
- •Cardiovascular disease (diagnosis, specified in protocol section 5.2.2)
- •Lipid disorder (diagnosis or prescription for the disease based on the NHG guidelines)
排除标准
- •Inability to understand and sign the informed consent form
- •Pregnancy
结局指标
主要结局
The prevalence of elevated albuminuria
时间窗: 1-2 weeks after invitation
defined as a confirmed urinary albumin creatinine ratio (UACR) ≥ 3.0 mg/mmol.
次要结局
- Average costs per subject(through study completion, an average of 5 weeks)
- The prevalence of unknown elevated albuminuria(through study completion, an average of 5 weeks)
- the proportion of invited subjects that was identified as having hidden kidney disease(through study completion, an average of 5 weeks)
