A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome
Not Applicable
Completed
- Conditions
- Pneumonia, Pneumocystis CariniiHIV Infections
- Registration Number
- NCT00002002
- Lead Sponsor
- Lederle Laboratories
- Brief Summary
The primary objective of the study is to evaluate the effectiveness of l-leucovorin in preventing toxicity from high dose trimethoprim / sulfamethoxazole (TMP / SMX) used as a therapy for Pneumocystis carinii pneumonia (PCP) in patients with AIDS.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie l-leucovorin's role in mitigating TMP/SMX toxicity in PCP treatment for AIDS patients?
How does the combination of l-leucovorin and trimethoprim/sulfamethoxazole compare to standard-of-care therapies for Pneumocystis Carinii Pneumonia in HIV-infected individuals?
Are there specific biomarkers that can predict which AIDS patients with PCP will benefit most from l-leucovorin adjunct therapy during TMP/SMX treatment?
What are the known adverse events associated with high-dose trimethoprim/sulfamethoxazole in AIDS patients and how does l-leucovorin co-administration affect their management?
What other folic acid antagonist combinations or alternative drugs have been explored for reducing PCP treatment toxicity in immunocompromised HIV/AIDS populations?
Trial Locations
- Locations (1)
San Francisco Gen Hosp
🇺🇸San Francisco, California, United States
San Francisco Gen Hosp🇺🇸San Francisco, California, United States