Efficacy of Antiplatelet Therapy for the Treatment of Chronic Recalcitrant Urticaria
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Weekly urticaria activity score
研究概览
简要总结
This study compares the combination of antiplatelets and antihistamine versus antihistamine alone for the treatment of chronic spontaneous urticaria
详细描述
This study is a randomized control trial comparing the effectiveness of the combination of antiplatelets and antihistamine and antihistamine alone for the treatment of chronic spontaneous urticaria
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
盲法说明
Identical capsules
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic spontaneous urticaria
- •D-dimer levels over 500 ng/ml
- •Not respond to a conventional dose of antihistamine
排除标准
- •Are taking aspirin
- •Have bleeding tendency
- •Have concurrent severe medical illnesses
研究组 & 干预措施
Desloratadine
Oral desloratadine 20 mg/day (antihistamine) for 4 weeks
干预措施: Desloratadine (Drug)
Desloratadine plus cilostazol and dipyridamole
Oral desloratadine 20 mg/day (antihistamine) in conjunction with cilostazol 150 mg/day and dipyridamole 50 mg/day (antiplatelets) for 4 weeks
干预措施: Desloratadine plus cilostazol and dipyridamole (Drug)
Desloratadine plus cilostazol and dipyridamole
Oral desloratadine 20 mg/day (antihistamine) in conjunction with cilostazol 150 mg/day and dipyridamole 50 mg/day (antiplatelets) for 4 weeks
干预措施: Desloratadine (Drug)
结局指标
主要结局
Weekly urticaria activity score
时间窗: 4 weeks
Urticaria activity score over 7 days (UAS7): scores 0-42 from mild to severe
次要结局
- D-dimer levels(4 weeks)
研究者
Assoc. Prof. Jettanong Klaewsongkram, MD.
Assoc. Prof. Jettanong Klaewsongkram, MD.
Chulalongkorn University