Muscle Blood Flow During Exercise

Completed

• Conditions: Skeletal Muscle Blood Flow
• Interventions: Other: Session 1-4; Other: Session 4; Other: Session 5

• Registration Number: NCT02070848
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear.

The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells.

Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-02-14
• Study First Submitted QC: 2014-02-24
• Study First Posted: 2014-02-25
• Study Start: 2018-09-01
• Primary Completion: 2018-10-19
• Study Completion: 2018-10-19
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-04
• Last Update Posted: 2021-03-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Non smoker or having stopped smoking for at least 5 yr
• Practice sports: physical activity level will be evaluated with a questionnaire (de Baecke et coll., 1982) and will give an activity index greater than 6 together with a VO2max greater than 50 ml/kg/min
• Body mass index lower than 25
• Registered to the French Social Security system
• Providing a written and informed consent to participate in the study

Exclusion Criteria

• History of venous or arterial thrombo-embolic events
• Bad perfusion from the cubital artery
• Unable to understand the information notice
• Subject exposed to law investigations or with financial dependancy
• Subjects feeling unwell whan seing blood.
• Subjects advised to not practice sport.
• Musculo-tendinous or articular issues with the lower leg
• Respiratory, cardiovascular or metabolic pathologies
• Current medical treatment that can not be stopped 7 days before the experiment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Concentric vs eccentric	Session 5	One arm study in which each subject will act as his own control.
Concentric vs eccentric	Session 1-4	One arm study in which each subject will act as his own control.
Concentric vs eccentric	Session 4	One arm study in which each subject will act as his own control.

Primary Outcome Measures

Name	Time	Method
Change in leg blood flow during concentric and eccentric muscle work	Leg blood flow measurements during exercises performed at the beginning, after 14 minutes, then after 18 min, 22 min, 26 min, 30 min, 33 min, 35 min and 45 min	Serial measures (9) of leg blood flow during concentric and eccentric muscle work are performed at the beginning of the exercise (t0), and then after 14 minutes (t14), after 18 minutes (t18), after 22 minutes (t22), after 26 minutes (t26), after 30 minutes (t30), after 33 minutes (t33), after 35 minutes (t35), and after 45 minutes (45) during each exercice, concentric and eccentric.

Trial Locations

Locations (1)

SERVICE DE PHYSIOLOGIE ET D'EXPLORATIONS FONCTIONNELLES - Nouvel Hôpital Civil; 🇫🇷 Strasbourg, France