Muscle Blood Flow Control During Exercise in Humans: Contribution From Mechanical and Metabolic Signals and Role of the Erythrocyte.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in leg blood flow during concentric and eccentric muscle work
研究概览
简要总结
Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear.
The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells.
Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Non smoker or having stopped smoking for at least 5 yr
- •Practice sports: physical activity level will be evaluated with a questionnaire (de Baecke et coll., 1982) and will give an activity index greater than 6 together with a VO2max greater than 50 ml/kg/min
- •Body mass index lower than 25
- •Registered to the French Social Security system
- •Providing a written and informed consent to participate in the study
排除标准
- •History of venous or arterial thrombo-embolic events
- •Bad perfusion from the cubital artery
- •Unable to understand the information notice
- •Subject exposed to law investigations or with financial dependancy
- •Subjects feeling unwell whan seing blood.
- •Subjects advised to not practice sport.
- •Musculo-tendinous or articular issues with the lower leg
- •Respiratory, cardiovascular or metabolic pathologies
- •Current medical treatment that can not be stopped 7 days before the experiment.
结局指标
主要结局
Change in leg blood flow during concentric and eccentric muscle work
时间窗: Leg blood flow measurements during exercises performed at the beginning, after 14 minutes, then after 18 min, 22 min, 26 min, 30 min, 33 min, 35 min and 45 min
Serial measures (9) of leg blood flow during concentric and eccentric muscle work are performed at the beginning of the exercise (t0), and then after 14 minutes (t14), after 18 minutes (t18), after 22 minutes (t22), after 26 minutes (t26), after 30 minutes (t30), after 33 minutes (t33), after 35 minutes (t35), and after 45 minutes (45) during each exercice, concentric and eccentric.
次要结局
未报告次要终点