The Effect of Acute and Chronic Exercise at the Metabolic Syndrome and Markers of Inflammation in Obese Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Aarhus University Hospital
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Changes in inflammatory markers as Adiponectin, MCP-1, Interleukin-6 and CRP. Moreover changes in body composition quantified with MRI
- Last Updated
- 17 years ago
Overview
Brief Summary
The human adipose and muscle -tissue produce and release a number of bioactive proteins which contributes to the chronic low grade of inflammatory status which is associated with obesity and plays an important role in the pathogenesis of type 2 diabetes and cardiovascular diseases.
Study 1: Our aim is to investigate if exercise has independent and additive effects in combination with diet-induced weight loss on circulating levels of inflammatory markers and mRNA levels in subcutaneous adipose tissue (SAT) and skeletal muscle tissue (SM.
Study 2: Our aim is to investigate whether gender and weight status plays a role in the metabolic response during two hours of acute exercise
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age 18-45 years,
- •obese (30 kg/m2 \< BMI \< 40 kg/m2) physically inactive (\<30 minutes pr. day)
- •and weight stabile for at least three months (± 2 kg of current body weight)
Exclusion Criteria
- •cardiovascular disease,
- •type 2 diabetes, pregnancy or orthopaedic difficulties causing inability to undertake an exercise program
Outcomes
Primary Outcomes
Changes in inflammatory markers as Adiponectin, MCP-1, Interleukin-6 and CRP. Moreover changes in body composition quantified with MRI
Time Frame: 8 weeks and 12 weeks
Change in Interleukin-6 and other inflammatory markers in plasma, adipose tissue and muscle tissue
Time Frame: 60, 120 240 minutes