Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities

University of Michigan1 site in 1 country45 target enrollmentDecember 13, 2021

ConditionsCellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities
Sponsor: University of Michigan
Enrollment: 45
Locations: 1
Primary Endpoint: mRNA expression of adipose tissue metabolic enzymes
Status: Completed
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1) low-intensity continuous exercise, 2) moderate-intensity continuous exercise, and 3) high-intensity interval exercise.

Registry

clinicaltrials.gov

Start Date

December 13, 2021

End Date

June 23, 2023

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Michigan

Responsible Party

Principal Investigator

Jeffrey F Horowitz

Professor of Movement Science and Director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology

University of Michigan

Eligibility Criteria

Inclusion Criteria

•Age:18-40
•Body Mass Index: 20-30 kg/m2
•Must engage in regularly planned aerobic-type exercise at moderate-vigorous intensity, 3 times per week for at least 30-60 minutes/session
•Women must have regularly occurring menses and must be premenopausal
•Subject willingness to opt-in for the Michigan Genomics Initiative (MGI) Repository

Exclusion Criteria

•Evidence/history of cardiovascular or metabolic disease.
•Taking anti-coagulate medications or medications known to affect metabolism or inflammation
•Weight instability ≥ ±3kg in the last 6 months
•Tobacco or e-cigarette users
•Women must not be pregnant or actively lactating