The Effects of Exercise Intervention on Skeletal Muscle and Other Organs in Aged Population and the Discovery of Associated Circulating Biomarkers
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Change in Physical performance
研究概览
简要总结
This project aims to investigate the intricate interplay between skeletal muscle and adipose tissue during the aging process by integrating human studies. Utilizing interventional research and randomized trials combined with examining blood samples from elderly individuals engaged in exercise, we aim to investigate the effects of exercise on muscle health and explore the underlying mechanisms of muscle aging and related biomarkers. Interdisciplinary research allowed us to investigate the systemic impact of exercise on muscles. This approach allowed us to gain a better understanding of the interconnectedness of skeletal muscle and adipose tissue in the aging process and devise efficient strategies to reverse age-related changes. These findings hold promise for promoting a future society where long and healthy life is achievable for all.
详细描述
This study is a randomized controlled trial of 6-month multidomain intervention program among community-living older adults with early physical impairments.
Inclusion criteria are: (1) community-dwelling adults aged ≥ 65 years, (2) slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women); subjects with the following conditions will be excluded: (1) established diagnosis of dementia, Parkinsonism or other neurodegenerative disease (2) disable status: mobilitylimiting conditions, (3) active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on, (4) estimated life expectancy <12 months, (5) current nursing home residents.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged ≥ 65 years
- •slow gait speed (<1 m/s in 6-meter walk test) or weakness (dominant handgrip strength <28 kg in men, <18 kg in women)
排除标准
- •established diagnosis of dementia, Parkinsonism or other mobility-limiting, disable conditions
- •active, acute diseases receiving treatment, such as cancer, heart failure, COPD and so on
- •estimated life expectancy <12 months
- •current nursing home residents
结局指标
主要结局
Change in Physical performance
时间窗: baseline, 6 month
Change in hand-grip strength (kg), or six-meter walking speed (m/s), or 5 times sit to stand test from baseline to 6 months in all participants
次要结局
- Change in DHEA-S(baseline, 6 month)
- Change in IGF-1(baseline, 6 month)
- Change in hs-CRP(baseline, 6 month)
- Change in Myostatin(baseline, 6 month)
- Change in Activing A(baseline, 6 month)
- Change in Follistatin(baseline, 6 month)
- Change in Relative appendicular skeletal muscle index (RASM)(baseline, 6 month)
- Change in body fat %(baseline, 6 month)
- Change in Cognitive performance(baseline, 6 month)
- Change from lipoproflie(baseline, 6 month)
研究者
Li-Ning Peng
Professor
National Yang Ming Chiao Tung University