Effect of Exercise Training on Skeletal Muscle Proteome Signature of Young Men
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Morten Hostrup, PhD
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Skeletal muscle proteome signature
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men
Detailed Description
Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.
Investigators
Morten Hostrup, PhD
Assistant Professor, PhD
University of Copenhagen
Eligibility Criteria
Inclusion Criteria
- •VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
- •Body mass index (BMI) of 19-26 kg/m2
- •Normal ECG (electrocardiography)
Exclusion Criteria
- •Serious adverse effects to exercise
- •Chronic disease
Outcomes
Primary Outcomes
Skeletal muscle proteome signature
Time Frame: Change from baseline proteome signature at 5 weeks
proteomics