Skeletal Muscle as a Mediator of Exercise Induced Effects on Metabolism & Cognitive Function: Role for Myokines & miRNAs
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 4
- 主要终点
- muscle microRNAs and myokines
研究概览
简要总结
The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction. Next the investigators would like to determine the shift in the muscle secretory activity induced by regular exercise intervention, which the investigators think could be translated into the beneficial changes in clinical phenotypes, determined by neuroimaging, cognitive function tests and metabolic phenotyping.
详细描述
Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in University Hospital Bratislava and in Institute of Experimental Endocrinology Slovak Academy of Sciences will be employed.
Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signed informed consent.
- •Diagnosed with Parkinson disease
- •Diagnosed with mild cognitive impairment (MCI) or Alzheimer disease (AD)
排除标准
- •Serious systemic cardiovascular, hepatic, renal disease, cancer.
- •Lack of compliance.
研究组 & 干预措施
'3 months exercise intervention program'
all participants will be subjected to 3 months supervised exercise intervention programme
干预措施: 3 months exercise intervention program (Behavioral)
结局指标
主要结局
muscle microRNAs and myokines
时间窗: up to 24 months
We will determine muscle bioactive secretory products (myokines \& miRNAs) that are regulated by acute bout of exercise in patients with neurodegenerative disease as well as in sedentary age, gender and BMI matched controls in association with their metabolic phenotype.
whole body energy metabolism
时间窗: up to 24 months
changes in whole body energy metabolism will be determined with indirect calorimetry. \& oral glucose tolerance test
motoric function
时间窗: up to 30 months
Proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy, motoric - balance testing
cognitive function
时间窗: up to 24 months
exercise related changes in cognitive \& motoric functions will be determined with the aid of questionaires, and proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy
次要结局
- Muscle functional tests(up to 30 months)
研究者
Jozef Ukropec
PhD
Slovak Academy of Sciences