Immune and Skeletal Muscle Response to an Exercise Session in Cancer Survivors
试验速览
- 阶段
- 不适用
- 入组人数
- 18
- 主要终点
- Exercise-induced response of circulating GDF-15
研究概览
简要总结
The aims of this study examine the immune system, muscle metabolism, and autonomic nervous system response to an acute bout of exercise. Cancer survivors will participate in an acute bout of exercise. Blood samples will be collected before the exercise bout and at two time points after the exercise bout to assess the proposed variables.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between the ages of 40-70 years
- •At least two years past detectible cancer (two years disease-free survival)
- •Have received chemotherapy and/or radiation as part of their cancer treatment
- •All cancers were of the organs/non-blood producing tissues (not blood/hematologic cancers) and while they were an adult (no history of pediatric cancer)
- •Meeting ACSM-AHA guidelines for exercise (150 minutes per week of cardiorespiratory fitness type exercises and ~two days per week of resistance training), as confirmed by a combination of a physical activity questionnaire and a cardiorespiratory fitness classification of "good" or higher (age and sex matched)
- •A BMI between 20-33 kg·m-2
- •Able to speak and read English
排除标准
- •Participants may not:
- •Have any contraindications to moderate to vigorous exercise
- •Have any recent illness or have been instructed not to exercise by a healthcare provider
- •Participants may not have range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)
- •Be taking medications (prescription or over the counter) known to influence immune function (including daily NSAID's and beta blockers), cholesterol-lowering medications (statins), drugs that increase bone mass (bisphosphonates), or steroids.
- •Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).
- •Be pregnant
- •Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study)
- •Fall outside of a BMI range of (20 - 33)
- •Consume alcohol or recreational drugs for 24h prior to visits
- •Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 2-3 times over the course of the study
结局指标
主要结局
Exercise-induced response of circulating GDF-15
时间窗: Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise
Circulating serum growth differentiation factor 15 before and after one exercise session
Exercise-induced response of circulating monocytes
时间窗: Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise
Circulating serum monocyte phenotype before and after one exercise session
Exercise-induced response of circulating T cells
时间窗: Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise
Circulating serum T cells phenotype before and after one exercise session
Exercise-induced response of circulating Follistatin
时间窗: Pre-exercise, change from pre-exercise to immediately post-exercise, change from pre-exercise to 1hr post-exercise, change from immediately post-exercise to 1hr post-exercise
Circulating serum follistatin before and after one exercise session
次要结局
- Body composition(before exercise)
- Body weight(before exercise)
研究者
Melissa M Markofski
Assistant Professor
University of Houston