The Role of Resolvin D1 in Maintaining Oral Health
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 26
- Locations
- 2
- Primary Endpoint
- Biochemical parameter (resolvin D1)
Study Overview
Brief Summary
The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.
A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Stage 3, Grade B and generalized periodontitis patients
Exclusion Criteria
- •excessive forces;
- •presence of systemic diseases
- •administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
- •having received non-surgical periodontal treatment within the past 6 months
- •allergy or sensitivity to any drug,
- •pregnancy, lactation
- •current and former use of tobacco.
Outcomes
Primary Outcomes
Biochemical parameter (resolvin D1)
Time Frame: Baseline and 1 month after NSPT
The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.
Secondary Outcomes
- Clinical attachment level (CAL)(Baseline and 1 month after NSPT)
- Gingival index (GI)(Baseline and 1 month after NSPT)
- Probing pocket depth(Baseline and 1 month after NSPT)
- Plaque index (PI)(Baseline and 1 month after NSPT)
Investigators
Ceren Gökmenoğlu
Principal investigator
Ordu University