What happens to the bacteria in the gut in patients who are receiving tube feeding with additional carbohydrate

Completed

• Conditions: Enteral tube feeding and fructo-oligosaccharides supplementation; Nutritional, Metabolic, Endocrine; Enteral Tube Feeding

• Registration Number: ISRCTN06446184
• Lead Sponsor: King's College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-01-18
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Intensive care unit (ICU) patients
2. Adult patients (both male and female)
3. Exclusive ETF with fibre formula

Exclusion Criteria

1. Patients receiving lactulose
2. Patients with gastrointestinal disease or gastrointestinal surgery
3. Patients currently receiving chemotherapy or gastrointestinal radiation therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in the colonic microbiota (measured using fluorescent in-situ hybridisation).

Secondary Outcome Measures

Name	Time	Method
1. Incidence of diarrhoea (measured using King's Stool Chart)<br>2. Faecal samples will be analysed for:<br>2.1. SCFA concentrations<br>2.2. pH<br>2.3. C. difficile enterotoxin A/B <br>2.4. Faecal secretory Immunoglobulin A (IgA)