Thermoregulatory Responses of Betaine Supplementation in Firefighters During Live Burn
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 2
- 主要终点
- Subjective measures
研究概览
简要总结
The goal of this clinical trial is to compare betaine supplementation to placebo in firefighters undergoing live burn training regarding thermoregulation and inflammation. The main questions it aims to answer are:
- Does betaine supplementation mitigate rises in core temperature during firefighter live burn training?
- Does betaine supplementation decrease inflammation from firefighter training?
- Does betaine supplementation increase total body water stores?
Participants will supplement with betaine for 1 month and complete:
- Total Body Water measures
- Body Composition measures
- Live Burn training with Core Temperature Measurements
- Provide Salivary samples
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Structural Firefighter
排除标准
- •• Participants have a cardiometabolic disease for which they take prescribed medications
- •Participants consume supplements known to impact hydration status or performance that they are not willing to stop taking for the study
- •Participants are pregnant
- •Female participants that have irregular menstrual cycles
- •Participants are injured and would not be able to fulfill the live burn scenario
- •Participants have sickle cell disease
- •Participants have experienced heat stroke within the last 2 years
结局指标
主要结局
Subjective measures
时间窗: immediately before and immediately after the completion of the live burn
Visual analog scales will be given to participants for subjective thermal sensation, rate of perceived exertion, and thirst
Thermoregulation
时间窗: 10 minutes before the live burn, during the ~15 minute live burn, 10, 20, and 30 minutes after the live burn.
Core temperature (Degrees C), skin temperature (Degrees C)
Stress (enzyme linked immunoassays)
时间窗: before, immediately after, 10 minutes, and 20 minutes after live burn
Salivary expression of Testosterone, Cortisol, interleukin-8, and interleukin 6 will be measured.
Sweat Rate
时间窗: immediately before and immediately after the completion of the live burn
Changes in body weight in kg will be used to find loss of sweat in L
Stress (respiration efficiency)
时间窗: immediately before and immediately after the completion of the live burn
Air tank pounds per square inch (PSI) will be recorded
Sweat Content
时间窗: immediately before and immediately after the completion of the live burn
Tegaderm patches will be worn during the live burn to analyze sodium concentration in sweat.
次要结局
- Chronic Stress (enzyme linked immunoassays)(Before supplementation and after 4 weeks of supplementation)
- Chronic Stress (vitals) professional firefighters.(Before supplementation and after 4 weeks of supplementation)
- Fluid Compartment Volumes (Bioelectrical Impedance Spectrocopy) professional firefighters.(Before supplementation and after 4 weeks of supplementation)
研究者
Michael J. Ormsbee
Director
Florida State University