Beta-alanine and Elder Endurance

Not Applicable

Completed

• Conditions: Physical Endurance
• Interventions: Dietary Supplement: Beta-alanine; Dietary Supplement: Placebo; Behavioral: Muscular endurance exercise

• Registration Number: NCT02821481
• Lead Sponsor: University of Miami

Brief Summary

The purpose for this study is to determine if beta-alanine supplementation combined with endurance-based resistance training can increase gains in muscular endurance to a greater extent than endurance-based resistance-training alone in older adults.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2016-06
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Study First Submitted: 2016-06-28
• Study First Submitted QC: 2016-06-28
• Study First Posted: 2016-07-01
• Status Verified: 2017-08
• Last Update Submitted: 2017-08-31
• Last Update Posted: 2017-09-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• 60-90 years of age
• Living independently (not residing in an assisted living facility)
• Through testing are found not to have sarcopenia
• Gait speed > 1 m/s
• Skeletal Muscle Index > 37% in men and > 27.6 % in women
• Exclusion Criteria
• Responding with a "yes" to any question on the PAR-Q.
• Are currently pregnant, or plan to try and become pregnant during the study
• Functional impairments that could impede the person's ability to participate in a resistance training program
• Current or recent use of supplements (within the past 3 months for non-alanine containing supplements or one year for supplements containing beta-alanine). Individuals taking only basic multivitamins (without any herbal co-ingredients) may still be allowed to participate. These situations will be reviewed on a case-by-case basis.
• Are currently enrolled in a regular exercise program (more than once per week)
• Current or recent smoker
• Use of medication containing corticosteroids
• Mini-mental score of 21 or below
• Severe musculoskeletal impairment
• Uncontrolled chronic disease
• Major depression
• Severe vestibular problems

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Exclusion Criteria

• Adults unable to consent
• Individuals who are not yet adults (infants, children, teenagers)
• Pregnant women
• Prisoners

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Beta-alanine and muscular endurance exercise	Beta-alanine	Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
Beta-alanine and muscular endurance exercise	Muscular endurance exercise	Receive 3.2 g/day beta-alanine and 3 days per week of endurance resistance training for 12 weeks
Beta-alanine without muscular endurance training	Beta-alanine	Receive 3.2 g/day beta-alanine with no endurance resistance training for 12 weeks
Placebo and muscular endurance exercise	Placebo	Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
Placebo and muscular endurance exercise	Muscular endurance exercise	Receive similar dextrose placebo and 3 days per week of endurance resistance training for 12 weeks
Placebo without muscular endurance training	Placebo	Receive similar dextrose placebo with no endurance resistance training for 12 weeks

Primary Outcome Measures

Name	Time	Method
Change in Performance of Daily Activities	baseline, 12 weeks	Short Physical Functional Performance test

Secondary Outcome Measures

Name	Time	Method
Change in Muscular Endurance	baseline, 12 weeks	20 repetitions to measure decline in muscular power across repetitions
Change in Muscular Strength	baseline, 12 weeks	Maximal weight that could be lifted one time (1RM)
Change in Body Fat	baseline, 12 weeks	Body fat assessment via bioimpedance

Trial Locations

Locations (1)

Max Orovitz Laboratories; 🇺🇸 Coral Gables, Florida, United States