NCT05496452Unknown不适用
Effect of Beta-lactoglobulin Supplementation on the Response of Muscle Protein Synthesis During Limb Immobilisation in Healthy Young Adults
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Muscle protein synthesis
研究概览
简要总结
The objectives of this study are to:
- Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse.
- Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.
详细描述
The objectives of this study are to:
- Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to 5 days of limb immobilisation will attenuate the decrease in integrated free-living rates of MPS during short-term muscle disuse.
- Establish whether combined β-lactoglobulin supplementation and resistance training for 1 week prior to limb immobilisation will attenuate the decrease in muscle mass and strength during short-term muscle disuse.
Hypotheses
- Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in integrated muscle protein synthesis, muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse.
- Combining β-lactoglobulin and resistance training for 1 wk prior to 5 d of limb immobilisation will attenuate the decrease in muscle fibre CSA, quadriceps muscle strength, and leg lean mass during muscle disuse.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blinded to supplement (beta-lactoglobulin or carbohydrate)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female
- •Aged 18-45 years
- •Physically active (≥150-300 minutes of moderate-intensity aerobic physical activity per week OR 75-150 minutes of vigorous-intensity aerobic physical activity per week)
- •Eumenorrheic and not taking any hormonal birth control (females)
排除标准
- •Dairy allergy or intolerance
- •Lower limb injury or surgery in the last 6 months,
- •Lower limb osteoarthritis or other musculoskeletal disorder
- •A musculoskeletal or blood blotting disorder
- •An allergy to local anaesthetic
- •Currently pregnant
- •Current use of blood thinning medications
- •Volunteers that take part in structured resistance exercise training
- •Taking supplements considered to be anabolic to skeletal muscle (protein supplements, creatine, or omega-3 supplements)
- •Consuming more than 1.2 grams of protein per kilogram of body mass per day in their habitual diet.
- •Volunteers involved in other studies at the time of enrolment
- •Volunteers who have taken part in a tracer study in the past 18 months
- •If without an understanding of verbal or written English
- •Volunteers with a history of eating disorders
结局指标
主要结局
Muscle protein synthesis
时间窗: 15 days
The synthesis of amino acids into new muscle protein.
次要结局
- Muscle mass(15 days)
研究者
研究点 (2)
Loading locations...
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