Effects of Betaine Supplementation on Strength and Muscle Creatine Content

Not Applicable

Completed

• Conditions: Healthy Subjects
• Interventions: Dietary Supplement: creatine; Dietary Supplement: betaine; Dietary Supplement: dextrose; Dietary Supplement: creatine plus betaine

• Registration Number: NCT01213719
• Lead Sponsor: University of Sao Paulo

Brief Summary

It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Study First Submitted: 2010-10-01
• Study First Submitted QC: 2010-10-01
• Study First Posted: 2010-10-04
• Primary Completion: 2011-07
• Study Completion: 2011-07
• Status Verified: 2012-01
• Last Update Submitted: 2012-01-12
• Last Update Posted: 2012-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• physically inactive
• non-obese

Read More

Exclusion Criteria

• skeletal muscle disturbance
• cardiovascular disturbance
• use of dietary supplements

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
creatine	creatine	will receive creatine monohydrate (20g/d) throughout 10 days
betaine	betaine	will receive betaine (2g/d) throughout 10 days
placebo (dextrose)	dextrose	will receive dextrose(20g/d)throughout 10 days.
creatine plus betaine	creatine plus betaine	will receive creatine (20g/d) plus betaine (2g/d) throughout 10 days

Primary Outcome Measures

Name	Time	Method
strength	after 10 days

Secondary Outcome Measures

Name	Time	Method
intramuscular creatine content	after 10 days

Trial Locations

Locations (1)

University of Sao Paulo; 🇧🇷 Sao Paulo, Brazil