The effect of pretreatment with a loading dose of intracoronary adenosine on periprocedural myonecrosis in patients undergoing percutaneous coronary intervention in the setting of non ST segment elevation acute coronary syndrome

Phase 3

Recruiting

• Conditions: on ST elevation acute coronary syndrome; Non ST elevation acute coronary syndrome; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12609000342213
• Lead Sponsor: Monash Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2009-05-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

Patients presenting with non ST segment elevation acute coronary syndrome (NSTEACS)

Exclusion Criteria

ST segment elevation myocardial infarction (STEMI), Cardiogenic Shock, bradycardia or Atrioventricular (AV) block, refractory ventricular arrhythmias, severe asthma, allergy to adenosine, totally occluded arteries resulting in TIMI grade 0 antegrade flow, pregnancy, unconscious or not for resuscitation,

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Periprocedural myocardial injury characterised by troponin and myocardial Creatine Kinase (CKMB) rise.[8 and 24 hrs after percutaneous coronary intervention (PCI)]

Secondary Outcome Measures

Name	Time	Method
Angiographic outcomes - Thrombolysis in myocardial infarction (TIMI) flow grade, Myocardial blush grade[At the end of PCI]