Comparison of Preconditioning Effect of High Dose and Low Dose Atorvastatin Treatment in Patients Underwent CABG

Phase 4

Conditions: Coronary Artery Bypass Surgery.
Atherosclerotic heart disease

Registration Number: IRCT2017080619470N61

Lead Sponsor: Vice Chancellor for Research, Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 100

Inclusion Criteria

patients who had been taking (atorvastatin 20 mg daily) at least one year prior to the cardiac surgery.
Exclusion criteria:
unstable angina; evidences of recent MI (within 6 months) ; history of cardiac surgery; congenital heart disease; history of cardiac arrhythmia (arterial fibrillation) before surgery; receiving anti- arrhythmic drugs (except Beta blockers) ; having pacemaker; left ventricle ejection fraction less than 30%, uncontrolled hypertension; arterial or ventricular arrhythmia; pregnancy; patient who are undergoing diabetes treatment; increased level of liver enzymes; renal failure with creatinine more than 2 mg/dl; active inflammation or immune deficiency; positive history of muscle disease or reaction to the stations.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The serum level of CPK-MB enzymes, troponin I. Timepoint: before induction of anesthesia and 24 ,48 hours after surgery. Method of measurement: Arterial blood sample.;High-sensitivity C-reactive protein (hs-CRP) levels,. Timepoint: before induction of anesthesia and 24 ,48 hours after surgery. Method of measurement: Arterial blood sample.;Mechanical ventilation duration in the ICU. Timepoint: After arrival to the ICU. Method of measurement: Observasion.

Secondary Outcome Measures

Name	Time	Method
Glomerular filtration rate (GFR) and urine output. Timepoint: After surgery in the intensive care unit. Method of measurement: observasion.;Blood glucose. Timepoint: After surgery in the intensive care unit. Method of measurement: blood sample.