Cefepime versus Cefoperazone/Sulbactum in combination with Amikacin as empirical antibiotic therapy in cancer patients with febrile neutropenia- A randomized clinical study

Jipmer0 个研究点目标入组 334 人开始时间: 待定最近更新: 2021年11月24日

试验速览

暂无简介。

•1.Diagnosis of hematological or solid malignancies
•2. Presence of neutropenia [defined as an absolute neutrophil count (ANC) <500 cells/mmÂ³ or if count <1000 cells/mmÂ³ and expected to fall <500 cells/mmÂ³ within 24â??48hours because of preceding chemotherapy
•3.Temperature >38ÂºC on two occasions at least 1 hr apart or 38.3Âº C on one occasion in 24 h in the absence of any other obvious cause of fever
•4.Both adult and pediatric FN patients
•5. Patients on oral antibiotic prophylaxis
•6.Administration of vancomycin for relavant indication will be allowed
•7.Previous evidence of fungal infection or patients on antifungal prophylaxis will be included

•1.History of hypersensitivity reactions and severe adverse events to beta-lactam antibiotics
•2.prior use of any antibiotic(s) within one week of index episode
•3.central nerve system infection, infective endocarditis, HIV infection
•4.Renal dysfunction (serum creatinine >2.0 mg/dl, or creatinine clearance <60ml/min)
•5.Hepatic dysfunction ( total bilirubin >2 mg/dl)
•6.Refractory hypotension at presentation
•7.Lack of informed consent

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