Non-invasive Prediction of Esophageal Varices in Liver Cirrhosis: A Multicenter Observational Study
- Conditions
- Liver CirrhosisEsophageal and Gastric Varices
- Interventions
- Procedure: Endoscopy
- Registration Number
- NCT02593799
- Lead Sponsor
- General Hospital of Shenyang Military Region
- Brief Summary
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.
- Detailed Description
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 363
- A diagnosis of liver cirrhosis.
- Age and sex are not limited.
- Etiology of liver cirrhosis is not limited.
- Routine laboratory data.
- Upper gastrointestinal endoscopy.
- Non-cirrhotic portal hypertension.
- Malignancy.
- Absent laboratory data.
- A previous diagnosis of esophageal varices.
- A previous history of variceal bleeding.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with esophageal varices Endoscopy Esophageal varices were confirmed by endoscopy. They were divided into "any grade" and "high-risk" varices. Patients without esophageal varices Endoscopy Patients without esophageal varices were divided into patients without "any grade" or "high-risk" varices.
- Primary Outcome Measures
Name Time Method Correlation of biochemical data with esophageal varices in liver cirrhosis 18 months The investigators firstly calculated the significant factors associated with the presence of esophageal varices, and then developed a score to predict the presence of esophageal varices in liver cirrhosis.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (17)
ANSTEEL Group Hospital
🇨🇳Anshan, Liaoning, China
First Affiliated Hospital of Dalian Medical University
🇨🇳Dalian, Liaoning, China
Friendship Hospital of Dalian City
🇨🇳Dalian, Liaoning, China
Central Hospital of Dandong City
🇨🇳Dandong, Liaoning, China
Central Hospital of Fushun City
🇨🇳Fushun, Liaoning, China
General Hospital of Mining Industry Group Fuxin
🇨🇳Fuxin, Liaoning, China
First Affiliated Hospital of Liaoning Medical University
🇨🇳Jinzhou, Liaoning, China
General Hospital of Liaoyang City
🇨🇳Liaoyang, Liaoning, China
Central Hospital of Panjin City
🇨🇳Panjing, Liaoning, China
General Hospital of Liaohe Oil Field
🇨🇳Panjing, Liaoning, China
Central Hospital Affiliated to Shenyang Medical College
🇨🇳Shenyang, Liaoning, China
Department of Gastroenterology, General Hospital of Shenyang Military Area
🇨🇳Shenyang, Liaoning, China
No. 1 of Department of Gastroenterology, Liaoning Provincial People's Hospital
🇨🇳Shenyang, Liaoning, China
No. 2 of Department of Gastroenterology, Liaoning Provincial People's Hospital
🇨🇳Shenyang, Liaoning, China
Shengjing Hospital of Chinese Medical University
🇨🇳Shenyang, Liaoning, China
Shuangshan Hospital of Anshan City
🇨🇳Anshan, Liaoning, China
First Affiliated Hospital of Chinese Medical University
🇨🇳Shenyang, Liaoning, China