Relationship Between Sperm Parameters and Metabolic Syndrome in a Infertile Couple Partner Man
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Male Infertility
- Sponsor
- Assistance Publique - Hôpitaux de Paris
- Enrollment
- 170
- Locations
- 1
- Primary Endpoint
- Number of spermatozoid and their relation with syndrome metabolic parameters
- Status
- Completed
- Last Updated
- 5 months ago
Overview
Brief Summary
Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility
Detailed Description
Assessment of sperm parameters and metabolic syndrome relations in men attending a Reproductive Biomedicine centre for an infertility of their couple. Secondary objectives are to study relationship between sperm parameters and: * adiposity and insulin resistance * inflammation * oxydative stress in blood and semen * hormonal status Innovative parameters will also be assessed to determine the quality of semen (length of fingers, wrist circumference and epigenetics studies)
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 to 45 years-old man
- •man consulting for primary or secondary infertility, with or without earlier notion of paternity
- •patient insured with a social security scheme
- •patient who have had a prior medical consultation
- •patient who have done informed and written consent to participate in the research study
Exclusion Criteria
- •patient with problems understanding French
- •patient smoking more than two-pack-a-day
- •patient monitoring for viral risk.
- •man with an unidiopathic infertility which may be explained by:
- •1\) identifiable factors in direct questioning at the sperm analysis:
- •exposure to toxic products
- •infectious disease history
- •pathological anatomical background 2) factors identified at the etiologic investigation: cytogenetic and genetic
Outcomes
Primary Outcomes
Number of spermatozoid and their relation with syndrome metabolic parameters
Time Frame: Day 0
We will measure the parameters of metabolic syndrome (triglycerides, HDL and LDL cholesterol, systolic and diastolic blood pressure, fasting glucose) and correlate them with the number of spermatozoid .
Secondary Outcomes
- Environmental parameters(Day 0)
- Relationship between spermogram and spermocytogram and other metabolic parameters(Day 0)