Epidemiological Characteristics and Prediction System of Acute Respiratory Distress Syndrome in China RICUs-CHARDS II Study
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- the prognosis of ARDS patients
研究概览
简要总结
This project intends to adopt the multicenter prospective real-world study method to conduct a preliminary study on the incidence, grading, risk factors, respiratory support strategies, in-hospital mortality, 3-month mortality, 6-month mortality, 1-year mortality, quality of life, lung function and limb function recovery, cognitive function, return to work and other conditions of ARDS patients in RICU. By collecting 1,000 patients, a clinical database related to ARDS in China was established to provide essential data and ideas for promoting standardized diagnosis and treatment technology for ARDS patients and further clinical intervention research. At the same time, ARDS biobank was established in China-Japan Hospital and Xiangya Hospital to realize the integration of clinical data and sample resources, and the prediction model of ARDS survival and complications of tuberculosis clinical data and biological samples was established by using big data and AI technology.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •New or worsening respiratory symptoms less than 7 days after the acute blow.
- •CT/X-ray: Double lung infiltration that cannot be fully explained by pleural effusion, lobar/whole atelectasis, and nodule.
- •Respiratory failure that cannot be explained by heart failure or fluid overload
- •After 15min assisted ventilation (PEEP or CPAP ≥ 5cmH2O) or HFNC with flow≥30L/min, PaO2/FiO2≤300mmHg
- •Classification of ARDS: mild (200mmHg < PaO2/FIO2 ≤ 300mmHg), moderate (100mmHg < PaO2/FIO2 ≤ 200mmHg), and severe (PaO2/FIO2 ≤ 100mmHg) and 4 ancillary variables for severe ARDS
排除标准
- •younger than 18 years old
- •Patients or family members refused to participate in the study
结局指标
主要结局
the prognosis of ARDS patients
时间窗: from 28d to 1 year
ICU mortality, 28-day mortality, 90-day mortality and 1-year mortality of ARDS patients
次要结局
- Incidence of ARDS in ICUs(2 years)
- Length of hospital stay in ARDS patients(during hospitalization)
- VFDs within 28 days(28 days)
- Long-term quality of life and long-term lung function(1 year)
- Rates of mechanical ventilation strategies are consistent with guidelines rates of rates of mechanical ventilation strategies consistent with guidelines(during hospitalization)
- Survival risk factors in hospitalized ARDS patients(during hospitalization)
- Risk factors for ARDS complications(during hospitalization)
研究者
Huang Xu
associate chief physician
China-Japan Friendship Hospital