Carbohydrate Use During and Following Exercise

Not Applicable

• Conditions: Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise
• Interventions: Dietary Supplement: Carbohydrate ingestion

• Registration Number: NCT01709617
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (\>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-10
• Study First Submitted: 2012-10-11
• Study First Submitted QC: 2012-10-16
• Last Update Submitted: 2012-10-16
• Study First Posted: 2012-10-18
• Last Update Posted: 2012-10-18
• Study Start: 2012-11
• Primary Completion: 2013-09
• Study Completion: 2014-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 17

Inclusion Criteria

• Healthy
• Male
• 18 - 40 years of age
• Endurance trained cyclist/triathlete
• VO2 max ≥ 50 ml/kg/min
• BMI < 25 kg/m2

Exclusion Criteria

• Use of medication
• Smoking

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Glucose-glucose	Carbohydrate ingestion	Glucose ingestion
Glucose-Fructose	Carbohydrate ingestion	glucose-fructose ingestion
disaccharide	Carbohydrate ingestion	Disaccharide ingestion

Primary Outcome Measures

Name	Time	Method
Exogenous carbohydrate oxidation rate (Part A)	180 min during trials 1-3	Carbohydrate oxidation as measured by breath samples
Endogenous carbohydrate oxidation (Part A)	180 min during trials 1-3	endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Glycogen utilization (Part B)	6 h post exercise during trials 4-6	Glycogen utilization measured through a muscle biopsy sample at post (\~90 min), 3 and 6 h post exercise.; Part B; trials 4-6.

Secondary Outcome Measures

Name	Time	Method
Indirect calorimetry (Part A)	every 30 min up to 180 min during trials 1-3	Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3
Plasma glucose	every 30 min up to 180 min during trials 1-6	Plasma glucose measurements
Plasma insulin	every 30 minutes up to 180 min during trials 1-6	plasma insulin measurements

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Limburg, Netherlands