How Does Altering the Timing of Pre-exercise Low-dose Caffeine Ingestion Affect Endurance Exercise Performance

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Caffeine powder -60; Other: Caffeine powder -30; Other: Caffeine powder 0; Other: Placebo powder -60; Other: Placebo powder 0; Other: Placebo powder -30

• Registration Number: NCT02985606
• Lead Sponsor: University of Exeter

Brief Summary

Investigate how manipulating the time between caffeine ingestion and exercise may alter exercise performance and cognition

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-11-30
• Study First Submitted QC: 2016-12-02
• Study First Posted: 2016-12-07
• Primary Completion: 2017-06-30
• Study Completion: 2018-09-15
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-11
• Last Update Posted: 2018-10-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 14

Inclusion Criteria

• vo2max > 55 ml/kg/min
• females on contraceptive pill

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Exclusion Criteria

• recent skeletal muscle injury
• cardiovascular injury
• metabolic disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Caffeine -60	Caffeine powder -60	Caffeine at 60 minutes prior to time trial
Caffeine -30	Placebo powder 0	Caffeine at 30 minutes prior to time trial
Caffeine 0	Placebo powder -30	Caffeine immediately prior to time trial
Caffeine -30	Placebo powder -60	Caffeine at 30 minutes prior to time trial
Caffeine 0	Placebo powder -60	Caffeine immediately prior to time trial
Caffeine -60	Placebo powder -30	Caffeine at 60 minutes prior to time trial
Placebo	Placebo powder -30	Placebo drink at all time points
Caffeine -60	Placebo powder 0	Caffeine at 60 minutes prior to time trial
Caffeine -30	Caffeine powder -30	Caffeine at 30 minutes prior to time trial
Caffeine 0	Caffeine powder 0	Caffeine immediately prior to time trial
Placebo	Placebo powder -60	Placebo drink at all time points
Placebo	Placebo powder 0	Placebo drink at all time points

Primary Outcome Measures

Name	Time	Method
Work done in kilojoules (kJ) during a 15 minute time trial on a cycle ergometer	15 minutes

Secondary Outcome Measures

Name	Time	Method
Collection of saliva for genotyping of CYP1A2	30 mintes
Change in plasma caffeine concentration and metabolites	2 hours 45 minutes
Change in cognitive function measured using stroop test	2 hours 45 minutes
Whole body fuel substrate utilisation measured using indirect calorimetry	10 minutes

Trial Locations

Locations (1)

Sport and Health Sciences; 🇬🇧 Exeter, Devon, United Kingdom