The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in Diffuse Parenchymal Lung Diseases
- Conditions
- Diffuse Parenchymal Lung Diseases
- Interventions
- Procedure: Transbronchial cryobiopsy
- Registration Number
- NCT03704233
- Lead Sponsor
- Guangzhou Institute of Respiratory Disease
- Brief Summary
The Diagnostic yield and Safety of transbronchial cryobiopsy in the diagnosis of diffuse parenchymal lung diseases are investigated in this multicenter, prospective and real world study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 350
- The patients are admitted in the institution as DPLD, while undefined after thorough history collection, laboratory examination and radiological data.
- Transbronchial cryobiopsy(TBCB) is indicated by clinicians for definitive diagnosis and patients are content with the examination with agreement signed.
- Blood gas analysis, routine blood test, ECG examination, coagulation function, immunological examination, chest HRCT, and liver/kidney function test have been completed.
- The radiological data indicates non-DPLD
- The clinical examinations mentioned above are not completed.
- The patient cannot endure or does not agree the procedure.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Cryobiopsy Transbronchial cryobiopsy Transbronchial cryobiopsy is performed in patients with undefined diffuse parenchymal lung diseases, and assess the diagnostic yield and safety.
- Primary Outcome Measures
Name Time Method Diagnotic yield two weeks Percentage of definitive pathological diagnosis by transbronchial cryobiopsy, the alteration of original diagnosis after transbronchial cryobiopsy
- Secondary Outcome Measures
Name Time Method Complication rate 12 weeks Incidence of bleeding, pneumothorax (during the procedure and within 7 days after the intervention) and exacerbations of DPLD related to the transbronchial cryobiopsy (in 12 weeks).
Trial Locations
- Locations (26)
Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
AnHui Chest Hospital
🇨🇳Hefei, Anhui, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
China-Japan Friendship Hospital
🇨🇳Beijing, Beijing, China
Xiamen Second Hospital
🇨🇳Xiamen, Fujian, China
Guangdong General Hospital
🇨🇳Guangzhou, Guangdong, China
the First Affiliated Hospital Sun Yat-sen University
🇨🇳Guangzhou, Guangdong, China
Peking University Shenzhen Hospital
🇨🇳Shenzhen, Guangdong, China
Southern Medical University Nanfang Hospital
🇨🇳Guangzhou, Guangdong, China
Shenzhen Guangming New District People's Hospital
🇨🇳Shenzhen, Guangdong, China
Affiliated Zhongshan Hospital of Guangdong Medical University
🇨🇳Zhongshan, Guangdong, China
Henan Provincial People's Hospital
🇨🇳Zhengzhou, Henan, China
The Central Hospital Of WuHan
🇨🇳Wuhan, Hubei, China
Department of Respiratory and Critical Care Medicine，Tongji Hospital，Tongji Medical College，Huazhong University of Science and Technology
🇨🇳Wuhan, Hubei, China
People's Hospital of Hunan Province
🇨🇳Changsha, Hunan, China
Dalian Muncipal Central Hospital Affiliated of Dalian Medical University
🇨🇳Dalian, Liaoning, China
The First Hospital of China Medical University
🇨🇳Shengyang, Liaoning, China
XiangYa Hospital Central South University
🇨🇳Changsha, Hunan, China
Shanghai Chest Hospital
🇨🇳Shanghai, Shanghai, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, Shanghai, China
Renji Hospital Affiliated to Shanghai Jiao Tong University
🇨🇳Shanghai, Shanghai, China
Xi'an chest hospital
🇨🇳Xi'an, Shanxi, China
West China School of Medicine/West China Hospital of Sichuan University
🇨🇳Chengdu, Sichuan, China
China Medical University Hospital
🇨🇳Taizhong, Taiwan, China
MianYang Central Hospital
🇨🇳MianYang, Sichuan, China
The first Hospital of Jiaxing
🇨🇳Jiaxing, Zhejiang, China