The Diagnostic Yield and Safety of Transbronchial Cryobiopsy in The Pulmonary Periphral Nodule
- Conditions
- Complication RateDiagnosis
- Interventions
- Procedure: Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep)
- Registration Number
- NCT04661956
- Lead Sponsor
- ShiYue Li
- Brief Summary
Transbronchial cryobiopsy under the guidance of endobronchial ultrasound is performed in patients with pulmonary peripheral nodule, and assess the diagnostic yield and safety.
- Detailed Description
Transbronchial cryobiopsy under the guidance of endobronchial ultrasound is performed in patients with pulmonary peripheral nodule, and assess the diagnostic yield and safety. This is a multi-center prospective randomized control trial.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
- The patients are admitted as Pulmonary Periphral Nodule, while undefined after thorough history collection, laboratory examination and radiological data.
- The longest diameter of the Pulmonary Periphral Nodule is less than 30mm in HRCT.
- The Pulmonary Periphral Nodule can be detected by radial-EBUS
- Transbronchial cryobiopsy(TBCB) is indicated by clinicians for definitive diagnosis and patients are content with the examination with agreement signed.
- Routine blood test, ECG examination, coagulation function, chest HRCT have been completed.
- The longest diameter of the Pulmonary Periphral Nodule is more than 30mm.
- The Pulmonary Periphral lesions cannot be detected by the radial endobronchial ultrasound.
- The clinical examinations mentioned above are not completed. The patient cannot endure or does not agree the procedure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Transbronchial cryobiopsy Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep) Transbronchial cryobiopsy was performed in the patiens of pulmonary peripheral nodule Transbronchial lung biopsy Transbronchial cryobiopsy/Transbronchial lung biopsy (forcep) Transbronchial lung biopsy was performed in the patiens of pulmonary peripheral nodule
- Primary Outcome Measures
Name Time Method Diagnotic yield six months Percentage of definitive pathological diagnosis by transbronchial cryobiopsy
- Secondary Outcome Measures
Name Time Method Complication rate one week Incidence of bleeding, pneumothorax (during the procedure and within 7 days after the intervention
Trial Locations
- Locations (24)
Xiamen Second Hospital
π¨π³Xiamen, Fujian, China
Lanzhou University Second Hospital
π¨π³Lanzhou, Gansu, China
The First Hospital of Lanzhou University
π¨π³Lanzhou, Gansu, China
Guangdong General Hospital
π¨π³Guangzhou, Guangdong, China
Southern Medical University Nanfang Hospital
π¨π³Guangzhou, Guangdong, China
Peking University Shenzhen Hospital
π¨π³Shenzhen, Guangdong, China
People's Hospital of Hunan Province
π¨π³Changsha, Hunan, China
Xi'an chest hospital
π¨π³Xi'an, Shanxi, China
Shanghai Chest Hospital
π¨π³Shanghai, Shanghai, China
First Affiliated Hospital of Xi'an Jiaotong University
π¨π³Xi'an, Shanxi, China
Hubei Provincial Hospital of Integrated Chinese & Western Medicine
π¨π³Wuhan, Hubei, China
XiangYa Hospital Central South University
π¨π³Changsha, Hunan, China
Shenzhen Guangming New District People's Hospital
π¨π³Shenzhen, Guangdong, China
The First Affiliated Hospital of Nanchang University
π¨π³Nanchang, Jiangxi, China
The First Hospital of Jiaxing
π¨π³Jiaxing, Zhejiang, China
Henan Provincial People's Hospital
π¨π³Zhengzhou, Henan, China
The First Affiliated Hospital of Bengbu Medical College
π¨π³Bengbu, Anhui, China
AnHui Chest Hospital
π¨π³Hefei, Anhui, China
China-Japan Friendship Hospital
π¨π³Beijing, Beijing, China
The Central Hospital Of WuHan
π¨π³Wuhan, Hubei, China
Shanghai Pulmonary Hospital
π¨π³Shanghai, Shanghai, China
Zhejiang Provincial People' s Hospital
π¨π³Huangzhou, Zhejiang, China
The First Affiliated Hospital Sun Yat-sen University
π¨π³Guangzhou, Guangdong, China
Zhongda Hospital Southeast University
π¨π³Nanjing, Jiangsu, China