The use of repetitive transcranial magnetic stimulation combined with home based exercise on motor and non motor symptoms in individuals with Parkinson disease
- Conditions
- The participant in this study is people with Parkinson disease.Brain stimulation, Gait performance, Parkinson disease, Home-base exercise
- Registration Number
- TCTR20230127001
- Lead Sponsor
- Faculty of Physical Therapy, Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 45
1) clinically diagnosed with PD stages 2 to 3 as assessed by the modified Hoehn and Yahr scale
2) the age groups between 50 and 75 years
3) taking PD medication regularly for at least a month
4) able to use smart phone for download metronome application
5) able to walk independently without any assistive device
6) able to follow commands and instructions
1.contraindication for TMS confirmed by TMS screening questionnaire 2.severe action or resting tremor 3. severe rigidity 4. ON/OFF medication fluctuations 5. severe disability from dyskinesia 6. Diagnosed with secondary parkinsonism 7. other neurological and/or musculoskeletal problems 8.implanted deep brain stimulation (DBS) or plan to have DBS during the study period
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Gait performance and balance Pre, post 10 sessions of rTMS stimulation, and post 8 weeks Gait performance will be reflected several outcomes such as time-up-and go and functional reach test
- Secondary Outcome Measures
Name Time Method Cortical outcomes Pre, post 10 sessions of rTMS stimulation, and post 8 weeks Cortical outcomes will be represented by corticomotor excitability (MEP) and cortical inhibition (CSP) that will be measured by a single-pulse TMS.