Effects of Cisatracurium on Sccinylcholine-induced Fasciculations
- Registration Number
- NCT02502032
- Lead Sponsor
- Zhuan Zhang
- Brief Summary
To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.
- Detailed Description
Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 87
- American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia;
- 20 - 65 years old;
- Without acid-base imbalance and electrolyte disturbance;
- With normal hepatic and renal function.
- Patients with the contraindications associated with succinylcholine or cisatracurium;
- Patients taking drugs known to alter the action of neuromuscular blockers;
- Patients with a body mass index exceeding 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cisatracurium 0.01 mg/kg Cisatracurium The group received pretreatment of cisatracurium 0.01 mg/kg. Cisatracurium 0.005 mg/kg Cisatracurium The group received pretreatment of cisatracurium 0.005 mg/kg. Cisatracurium 0.02 mg/kg Cisatracurium The group received pretreatment of cisatracurium 0.02 mg/kg.
- Primary Outcome Measures
Name Time Method Presence of fasciculations After the injection of succinylcholine for 1.5 minutes
- Secondary Outcome Measures
Name Time Method Side effects of the pretreatment of cisatracurium From the time of 3 minutes after the pretreatment of cisatracurium for 0.5 minutes The time to maximal depression of twitch From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes The extent to maximal depression of twitch From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes The grades of endotracheal intubation At intubating time The changes of serum potassium After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation Myalgia at 24 hours postoperatively At 24 hours postoperatively