The Influence of Noradrenergic Activity on Attentional Control in Younger and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 164
- 试验地点
- 1
- 主要终点
- Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker
研究概览
简要总结
Older adults demonstrate increased distractibility by task-irrelevant information which contributes to general cognitive impairment. However, it is yet unclear how changes in noradrenergic activity during aging influences attentional control. In the current study, tonic noradrenergic activity will be increased or decreased to investigate its behavioral and neural effects on attentional control.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fluent in English
- •Aged between 18-35 or 50-80
- •Have normal or corrected-to-normal vision and hearing, and normal color vision
- •Have a mobile phone and email address
排除标准
- •Non-English speakers
- •Currently practicing any relaxation, meditation, or breathing technique for more than an hour per week
- •Have participated in studies measuring attentional capture in the past year
- •Experiencing symptoms of dementia
结局指标
主要结局
Initial Eye-movements Toward Target and Distractor Shapes Measured by an Eye-tracker
时间窗: Calculated once at the end of the 1 day experiment
The oculomotor suppression effect is a lower likelihood that salient display items will be the target of the initial eye movement in a visual search task compared to nonsalient display items. This effect is calculated from the percentage of first saccades toward a non-target stimuli subtracted by the percentage of first saccades toward the distractor stimuli. Greater % of first saccades toward the target would demonstrate better goal-directed attentional control and greater % of first saccades toward the distractor would demonstrate increased distractibility. Thus, a greater oculomotor suppression effect would demonstrate an increased ability to inhibit salient information that is irrelevant to the task.
次要结局
未报告次要终点
研究者
Mara Mather
Principal Investigator
University of Southern California