Older People and Enhanced Neurocognitive function study

Not Applicable

Completed

Conditions: erve and cognitive function
Nervous System Diseases
Cognitive function

Registration Number: ISRCTN54195799

Lead Sponsor: ondon School of Hygiene and Tropical Medicine (LSHTM) (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 200

Inclusion Criteria

1. Healthy volunteers
2. Aged 75 years and over, either sex
3. Defined low B12 status (greater than 107 pmol/l and less than 210 pmol/l)
4. No previous history of diabetes or dementia

Exclusion Criteria

1. Pre-existing type I or type II diabetes at baseline
2. Pre-existing dementia at baseline
3. Currently consuming vitamin B12 on a daily basis
4. Mini-Mental State Examination (MMSE) score less than 24 at baseline screen
5. Very low B12 (below 107 pmol/l - Beckman Coulter assay)
6. B12 levels above 210 pmol/l
7. Anaemic
8. History of epilepsy
9. Those with implanted metallic devices such as a pacemaker
10. Alcoholics

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Amplitude of tibial motor evoked responses and tibial nerve conduction velocity, measured at 12 months.

Secondary Outcome Measures

Name	Time	Method
1. Cognitive function: immediate recall, prospective memory, letter search/cancellation, verbal fluency, symbol digit modalities, simple and choice reaction time<br>2. Timed up and go<br>3. Psychological health (mood) using the 30-item General Health Questionnaire (GHQ-30)<br>4. Height and weight <br>5. History of myocardial infarction (MI) and stroke (reported hospitalisation) <br><br>All outcomes measured at 12 months.