Effect of Lumbar Proprioceptive Training on Cortisol, Proinflammatory Cytokines, Pain and Functional ability in Patients with Lumbar Radiculopathy.

Not Applicable

• Conditions: Nervous System Diseases

• Registration Number: PACTR202308709555945
• Lead Sponsor: Faculty of Physical Therapy

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-24
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1) The patients with (L4, L5) (L5, S1) disc herniation with radiculopathy referred from neurological or orthopedic department after doing MRI of lumbar spine.
2) Patients age ranged from 30 -45 years old.
3) The duration from onset of pain was from 3-12 months.
4) The selected patients in the study were ambulant independently.

Exclusion Criteria

1)Patients with any pathology preventing neural tissue testing (eg: restriction of joint range of motion, lumbar myelopathy, fracture, instability).
2)Patients with history of previous lumbar surgery, gross neurological deficits and inflammatory arthritis.
3)Patients with medical red flags as severe psychiatric disorder or cognitive deficits.
4)Medically unstable and uncooperative patients.
5)Causes of hyper cortisolism other than radiculopathy as diabetes, chronic renal failure, pituitary or adrenal gland tumor.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of serum cortisol level was done for each patient by using immulite ® 2000 systems analyzers. Measurement of pro inflammatory cytokines level was done for each patient by using Stat Fax 2100 Microplate Reader device.

Secondary Outcome Measures

Name	Time	Method
Pain intensity Pain was assessed by using a visual analog scale (VAS).Functional ability was evaluated by Modified Oswestry Low Back Disability Questionnaire